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Antibiotics

Azicine 250 mg

 

Pack size:

Box of 6 sachets x 1.5 g.

 

Composition:

Each sachet contains azithromycin (dihydrate) 250 mg.

 

Shelf-life:

24 months from the date of manufacturing.

Store in a well-closed container, in a dry place. Do not store above 30oC.

 

  • Indications and Dosage & Administration
  • Contraindications
  • Adverse reactions
  • Precautions

  • Azithromicin is indicated for the treatment of infections:
  • Upper respiratory tract infections: ear, nose and throat infections like sinusitis, tonsillitis, otitis media,...
  • Lower respiratory tract infections: pneumonias, acute bronchitis.
  • Skin and soft tissue infections: furunculosis, pyoderma, impetigo due to Staphylococcus aureus
  • Sexually transmitted diseases: urethritis and cervicitis, non-gonococcal urinary tract infections and pelvises.
     
  • Azicine 250 mg is orally administered. Dissolved in warm water.
  • Adults:
    Upper and lower respiratory tract infections, skin and soft-tissue infections:
    Initial dosage is 500 mg as a single dose on the first day and followed by 250 mg once daily for 4 days.
    Sexually transmitted diseases: 1 g as a single dose.
  • Children:
    One single dose of 10 mg/kg/day for 3 days.
    Administer at least 1 hour before or 2 hours after a meal.


Or as prescribed by physicians.



 

  • Known hypersensitivity to azithromycin, erythromycin, or any macrolide antibiotic.

 

  • As for erythromycin, azithromycin is well tolerated with a low incidence of side effects (approximately 13% of all treated patients). The most frequent adverse reactions of azithromycin are gastrointestinal disturbances (10%) in origin with nausea, abdominal discomfort (pain/ cramps), vomiting, flatulence, diarrhea, and loose stools being occasionally observed, but they are usually mild and less frequent than with erythromycin. Transient elevations of liver enzyme values ave been reported. Rashes, headache, and dizziness may occur. Transient alterations in neutrophil counts have been seen in patients receiving azithromycin.
  • Hearing impairment: In investigational studies where higher doses were used for prolonged periods of time, reversible hearing impairment was seen in some patients.
  • Common:
    Nausea, diarrhea, pain, vomiting.
  • Less common:
    Fatigue, headache, vertigo, somnolence.
    Flatulence, dyspepsia, appetite loss.
    Skin eruptions, itch.
    Vaginosis, colpitis
  • Rare:
    Anaphylactic reaction, angoedema, elevated transaminase, slight transient decrease ofneutrophil.

     

  • The use ofthe drug is not recommended in children under 6 months.
  • Serious hypersensitivity reactions, including angioedema, anaphylaxis, and dermatologic reactions, have occurred rarely in patients receiving azithromycin.
  • Because azithromycin is eliminated principally via the liver, the drug should be used with caution in patients with impaired hepatic function.
  • Because of limited data regarding use of azithromycin in patients with renal impairment, the drug should be used with caution in patients with glomerular filtration rates less than 10 ml/minute.
  • Prolonged cardiac repolarization and QT interval with risk of cardiac arrhythmiaand torsades de pointes has been reported rarely with macrolides.
  • The possibility of such effects with azithromycin cannot be completely ruled out in patientsat increasedrisk forprolongedcardiacrepolarization.
  • To reduce development of drug-resistant bacteria and maintain effectiveness of azithromycin and other antibacterials, the drug should be used only for the treatment or prevention of infections proven or strongly suspected to be caused by susceptible bacteria.
  • There are no adequate and controlled studies to date using azithromycin in pregnant women, and the drug should be used during pregnancy only when clearly needed.
  • Azithromycin has been detected in human milk. The drug should be used with caution in nursing women.
  • There is no evidence to suggest that azithromycin may have an effect on a patient's ability to drive or operate machinery.
     

Contact us

FACTORY 1: K63/1 Nguyen Thi Soc St., Xuan Thoi Dong, Hoc Mon, HCMC
Tel: +84 28 3718 2141 - Fax: +84 28 3718 2140

FACTORY 2: 40 Tu Do Avenue, VietNam-Singapore Industrial Park, Binh Duong
Tel: +84 274 376 7470 - Fax: +84 274 376 7469
Email : stada@stada.com.vn
Website: www.stada.com.vn



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