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Cardiovascular Agents

Lisiplus STADA 10/12,5 mg

 

Pack size:

Box of 3 blisters x 10 tablets.


Composition:

Each tablet contains lisinopril 10 mg and hydrochlorothiazid 12.5 mg.


Shelf-life:

36 months from the date of manufacturing.

Store in a well-closed container, in a dry place. Protect from light. Do not store above 30oC.

 

  • Indications and Dosage & Administration
  • Contraindications
  • Adverse reactions

  • Treatment of essential hypertension in patients where combination therapy is appropriate.
     
  • Administered orally.
  • The usual dosage: One tablet, administered once daily. Lisiplus STADA® should be taken at approximately the same time each day. In general, if the desired therapeutic effect cannot be achieved in a period of 2 to 4 weeks at this dose level, the dose can be increased to two tablets administered once daily.
  • Renal insufficiency:
    Lisiplus STADA® is not to be used as initial therapy in any patient with renal insufficiency.  
    In patients with creatinine clearance of > 30 and < 80 ml/min, Lisiplus STADA® may be used, but only after titration of the individual components.
  • Prior diuretic therapy:
    The diuretic therapy should be discontinued for 2 - 3 days prior to initiation of therapy with Lisiplus STADA®. If this is not possible, treatment should be started with lisinopril alone, in a 5 mg dose.
  • Elderly:
    No adjustment of dosage is required in the elderly. In clinical studies the efficacy and tolerability of lisinopril and hydrochlorothiazide, administered concomitantly, were similar in both elderly and younger hypertensive patients.
  • Paediatric use:
    Safety and effectiveness in children have not been established.


Or as prescribed by physicians.

 

  • Hypersensitivity to lisinopril, to any ingredient of the drug or any other angiotensin converting enzyme (ACE) inhibitor.
  • Hypersensitivity to hydrochlorothiazide or other sulphonamide-derived drugs.
  • History of angioedema with previous ACE inhibitor therapy.
  • Aortic valvular stenosis, obstructive cardiomyopathy.
  • Unilateral or bilateral renal artery stenosis.
  • Hereditary or idiopathic angioedema.
  • Second and third trimesters of pregnancy.
  • Severe renal impairment (creatinine clearance < 30 ml/min).
  • Anuria.
  • Severe hepatic impairment.

Lisinopril

  • Common:
    Headache, persistent and nonproductive cough.
  • Uncommon:
    Nausea, taste disturbances, diarrhea, hypotension, rash, maculopapular, urticaria with or without itch, fatigue, proteinuria, fever or arthralgia.
  • Rarely:
    Angioedema, hyperkalemia, confusion, irritability, numbness or tingling feeling in lips, hands and legs, oligopnea, dyspnea, chest pain, neutropenia, granulocytopenia, hepatotoxic, jaundice, cholestasis, hepatic necrosis and cell lesions, pancreatitis.

Hydrochlorothiazide

  • Common:
    Fatigue, dizziness, vertigo, headache, hypokalaemia, hyperuricaemia, hyperglycaemia, hyperlipaemia (high dose).
  • Uncommon:
    Orthostatic hypotension, arrhythmias, nausea, vomitting, anorexy, constipation, diarrhea, intestinal spasm, urticaria, rash, photosensitivity, hypomagnesemia, hyponatraemia, hypercalcemia, hypochloremic alkalosis, hypophosphatemia.
  • Rarely:
    Anaphylactic reactions, fever, leucopenia, agranulocytosis, thrombocytopenia, aplastic anaemia, haemolytic anaemia, paraesthesia, sleep disturbances, depression, vasculitis, rash, haemorrhage, hepatitis, jaundice, intrahepatic cholestasis, pancreatitis, dyspnoea, pneumonitis, pulmonary oedema, renal failure, interstitial nephritis, impotence, blurred vision.

     

Contact us

FACTORY 1: K63/1 Nguyen Thi Soc St., Xuan Thoi Dong, Hoc Mon, HCMC
Tel: +84 28 3718 2141 - Fax: +84 28 3718 2140

FACTORY 2: 40 Tu Do Avenue, VietNam-Singapore Industrial Park, Binh Duong
Tel: +84 274 376 7470 - Fax: +84 274 376 7469
Email : stada@stada.com.vn
Website: www.stada.com.vn



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